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M TransMedics® TRANSMEDICS GROUP, INC. 200 MINUTEMAN ROAD SUITE 302 ANDOVER, MA 01810 Your Vote Counts! TRANSMEDICS GROUP INC 2022 Annual Meeting Vote by May 31, 2022 11 :59 PM ET You invested in TRANSMEDICS GROUP INC and it•s time to vote! You have the right to vote on proposals being presented at the Annual Meeting. This is an important notice regarding the availability of proxy material for the shareholder meeting to be held on June 01, 2022. Get informed before you vote View the Notice & Proxy Statement, Form 1 0-K online OR you can receive a free paper or email copy of the material(s) by requesting prior to May 18, 2022. If you would like to request a copy of the material(s) for this and/or future shareholder meetings, you may (1) visit, (2) call 1-800-579-1639 or (3) send an email to If sending an email, please include your control number (indicated below) in the subject line. Unless requested, you will not otherwise receive a paper or email copy. Smartphone users Point your camera here and vote without entering a ~I number *Please check the meeting materials for any special requirements for meeting attendance. Vote Virtually at the Meeting* June 01, 2022 8:00AM EDT Virtually at:!TMDX2022


Vote at THIS IS NOT A VOTABLE BALLOT This is an overview of the proposals being presented at the upcoming shareholder meeting. Please follow the instructions on the reverse side to vote these important matters. Voting Items 1 . Election of Directors Nominees: 1 a. Waleed Hassanein, M.D. 1 b. James R. Tobin 1c. Edward M. Basile 1 d. Thomas J. Gunderson 1 e. Edwin M. Kania, Jr. 1 f. Stephanie Lovell 1 g. Merilee Raines 1 h. David Weill, M.D. 2. To approve, on a non-binding advisory basis, the compensation paid to TransMedics’ named executive officers. 3. To approve, on a non-binding advisory basis, the frequency of TransMedics’ future “say on pay” votes. 4. To approve an amendment to the TransMedics Group, Inc. 2019 Stock Incentive Plan to increase the maximum aggregate number of shares of common stock that may be issued pursuant to awards granted under the TransMedics Group, Inc. 2019 Stock Incentive Plan by 1,500,000 shares. 5. To ratify the appointment of PricewaterhouseCoopers LLP as TransMedics Group, Inc.’s independent registered public accounting firm for the fiscal year ending December 31, 2022. NOTE: Such other business as may properly come before the meeting or any adjournment thereof. Board Recommends 0 For 0 For 0 For 0 For 0 For 0 For 0 For 0 For 0 For 0 For 0 For 0 For Prefer to receive an email instead? While voting on, be sure to click “Sign up forE-delivery”.